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  #5,962,332
Detection of trinucleotide repeats by in situ hybridization.
inventors: Robert H Singer, Krishan L Taneja
Filed on December 11, 1995, awarded on October 5, 1999.

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Disclosed is a method of detecting a trinucleotide repeat expansion by in situ hybridization. The disclosed method uses a sample of nucleated cells, a labeled trinucleotide repeat-specific probe and detection of the hybridized probe by a means whose sensitivity distinguishes between the signal from probes hybridized to an expanded repeat and the signal from probes hybridized to a non-expanded repeat.
 
 
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