Publications

 14. Biochemical and structural characterization of the GEM GTPase.
Splingard, A, Ménétrey, J, Perderiset, M, Cicolari, J, Regazzoni, K., Hamoudi, F, Cabanié, L, El Marjou, A, Wells, A, Houdusse, A, and de Gunzburg, J.
J Biol Chem 282:1905-1915. (2007)

13.  Electrospray Ionization Mass Spectrometry Studies of Noncovalent Myosin VI Complexes Reveal a New Specific Calmodulin Binding Site.
Chevreux G., Potier N., Van Dorsselaer A., Bahloul A., Houdusse A., Wells A., Sweeney HL.  
J Am Soc Mass Spectrom. Jun 23. (2005)

12.  The structure of the myosin VI motor reveals the mechanism of directionality reversal.
 Ménétrey* J., Bahloul* A., Wells, A.L., Yengo, C.M., Morris, C.A., Sweeney, H.L. & Houdusse, A.
 Nature 435:779-785. (2005)
*both authors contributed equally

11.  Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.
Wang W, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E, Singer RH, Segall JE, Condeelis JS.
Cancer Res. 64(23):8585-94. (2004)

10. The unique insert in myosin VI is a structural calcium-calmodulin binding site.
Bahloul A., Chevreux G., Wells A.L., Martin D., Nolt J., Yang Z., Chen L-Q., Potier N., Van Dorsselaer A., Rosenfeld S., Houdusse A., Sweeney H.L.
Proc. Natl. Acad . Sci. U.S.A. 98:13655-9. (2004)

9. The myosin V motor visualized at 2Å without bound nucleotide reveals a new structural state of myosin. 
Coureux, P.-D., Wells, A.L., Ménétrey, J., Yengo, C.M., Morris, C.A., Sweeney, H.L., and Houdusse, A. 
Nature 425:419-423. (2003)

8.   An actin-dependent  conformational change in myosin.
Xiao, M., Reifenberger, J.G., Wells, A.L., Baldacchino, C., Chen, L.-Q., Ge, P., Sweeney, H.L., and Selvin, P.R.   
Nature Struct. Biol. 10:402-408. (2003) 

7.   Calcium functionally uncouples the heads of myosin-VI.
Morris, C.A.*, Wells, A.L.*, Baldacchino, C., Chen, L-Q, and Sweeney, H.L.   
J. Biol. Chem.  278:23324-23330. (2003)
*both authors contributed equally

6.   Myosin VI is a processive motor with a large step size.
Rock R.S., Rice S.E., Wells A.L., Purcell T.J., Spudich J.A., and Sweeney H.L.     
Proc. Natl. Acad . Sci. U.S.A. 98:13655-9. (2001)

5.   Actin and light chain isoform dependence of  myosin V kinetics.
De La Cruz, E.M., Wells, A.L., Sweeney, H.L., and E.M. Ostap   
Biochemistry 39:14196-14202.  (2000).

4.   Kinetic and Spectroscopic Evidence for Three Actomyosin:ADP States in Smooth Muscle.
Rosenfeld, S.S., Xing, J., Whitaker, M., Cheung, H.C., Brown, F., Wells, A., Milligan, R.A. and Sweeney, H.L. 
J. Biol. Chem.  275:25418-25426. (2000)

3.   The kinetic mechanism of myosin-V.
De La Cruz, E.M., Wells, A.L., Rosenfeld, S.S., Ostap, E.M., and Sweeney, H.L.   
Proc. Natl. Acad. Sci. U.S.A .96:13726-13731. (1999)

2.   Myosin-VI is an actin-based motor that moves backwards.
Wells, A.L., Lin, A.W., Chen, L.-Q., Safer, D., Cain, S.M., Hasson, T., Carragher, B.O., Milligan, R.A., and Sweeney, H.L. 
Nature 401:505-508. (1999) 

1.   In vivo expression of full-length human dystrophin from adenoviral vectors deleted of all viral genes.
Haecker, S.A., Stedman, H. H., Balice-Gordon, R. J., Smith, D.B.J., Greelish, J.P., Mitchell, M.A., Wells, A., Sweeney, H.L., and Wilson, J.M.
Hum. Gene Therapy 7:1907-1914. (1996)