Oleynikov & Singer (2003): Figure 7

Supplementary Material From Singer Lab Publications:

Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localization

Curr Biol 13(3):199-207 (2003 February 4)

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Figure 7. Proposed Model of ZBP1-mRNA Localization

The travels of ZBP1. ZBP1 shuttles into and out of the nucleus. If it encounters the nascent zipcode sequences, it binds there as the nascent RNA and finishes transcription and processing/polyadenylation before export to the cytoplasm. Once in the cytoplasm, it associates with cytoskeletal elements (actin filament bundles are shown here) and localizes to the leading edge.