Figure 5. Model of the Particle Movement

The schematic depicts the particle moving directly on actin filaments via She1p in budding yeast. Because She3p was visualized as part of the particle, it is represented along with other, as yet unknown, components. She2p and She4p act on the formation of the particle, illustrated by the arrows. She5p traps the particle at the bud neck. Actin filaments are represented with the barbed end as the arrowhead. The mixed polarity is interpreted from the bidirectional movement of the particle. Once in the bud, the particle stays there, so that the actin filaments with opposite polarity are represented as discontinuous at the neck. Anchors represent potential points of attachment of the particle.