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Fig.
4. Transcriptional response of fibroblasts to serum. (A)
The kinetics of activation of transcription for the 11 genes assayed
was relatively similar, in contrast with results obtained through microarray
analysis. Here, two serum-responsive genes, ß-actin and c-fos,
are shown to be similar, yet only c-fos activation was detected on microarray.
(B) Increases in visualized transcription sites 10 min after
serum induction, relative to starved controls. (C) Activation
curve for all assayed genes over a time course of serum induction, showing
how allele and gene prevalence change as the cascade progresses. In
(A) and (C), extrapolated time points are shown in brackets. |
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